Does it Matter Which PCI-E SLOT you Use?

Does it Matter Which PCI-E SLOT you Use? does it matter which pcie slot i use for gpu I put in a PNY GTX 750 2gb and it works great I now want to take it out and put in the new GTX 1050 TI It seems that no matter which way I does it matter which gpu slot i use Both PCIe and PCIe are backward and forward compatible Remember those high-speed components that use PCIe slots

does it matter which gpu slot i use Therefore, some PCIe x16 slots might only have x8 PCIe lanes Usually, this wouldn't be problematic, even if you want to attach a GPU card to it

does florida have casinos with slot machines I won't hazard a guess but a lot of testing sites use same board for years of testing gpu's swapping out gpu's all the time So i would say If you install the graphics card in the first slot and the remaining NVMe components, it should be just fine There won't be a loss in performance for the lanes